For the project titled “A New Molecular Switch in Thyroid Cancer.” This research will focus on a modified (phosphorylated) version of the PBF protein, as high PBF levels have been linked with more aggressive thyroid tumors and resistance to radioactive iodine treatment. The research will investigate the hypothesis that PBF-Y174 is a central thyroid signaling event that is dysregulated in thyroid tumors, in order to improve understanding of thyroid tumors and consider PDF phosphorylation as a potential new drug target for the treatment of thyroid cancer.