For the project “Overexpression of LGR4 and LGR5 in Human Thyroid Cancer Promotes Wnt/β-Catenin Signaling and is Associated with Tumor Aggressiveness.” This project will focus on understanding the role of specific pathways and markers in nodal metastases and aggressive tumor behavior, with this understanding aiding potential development of novel therapeutics in metastatic papillary thyroid cancer that is unresponsive to current therapies. This grant is the 2013 Ric Blake Memorial Thyroid Cancer Research Grant.