Glenn J. Hanna, M.D.
For the project titled “Correlating the Circulating Immune Profile with Response to Dual Immune Checkpoint Inhibition in Advanced Thyroid Cancer.” This project is applicable to advanced medullary thyroid cancer as well as differentiated thyroid cancer and focuses on identifying predictors or response or resistance to immune checkpoint two immune checkpoint inhibitors. Immune checkpoint inhibitors have demonstrated clinical benefit in a wide range of solid tumors. The research will profile the tumor microenvironment in immunotherapy-treated patients using multiparametric flow cytometry with the aim of correlating these findings with a novel, circulating immune checkpoint profiling assay. This grant is this year’s Ric Blake Memorial Thyroid Cancer Research Grant, named for ThyCa Co-Founder Ric Blake.